Article

New molecular signatures defining the differential proteostasis response in ALS-resistant and -sensitive motor neurons

2022-04-10

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal adult neurodegenerative disease characterized by proteostasis dysregulation, resulting in progressive loss of spinal and upper motor neurons. A subset of cranial motor neurons resistant to ALS-stress survive until late stages of the disease. To investigate these differences, we exploited a unique platform of induced cranial and spinal motor neurons (iCrMNs and iSpMNs,...

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Literature Corpus work: 1df7e15f-58a9-5a4c-ab32-4be2924a0ee4
DOI: 10.1101/2022.04.10.487765

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