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Proteostasis and Unfolded Protein Response Dynamics in Human Neuron and Mouse Glia Co-culture Reveal Cell-Specific Aging Responses

2025-08-13

Abstract excerpt

Proteostasis, or protein homeostasis, is a tightly regulated network of cellular pathways essential for maintaining proper protein folding, trafficking, and degradation. Neurons are particularly vulnerable to proteostasis collapse due to their post-mitotic and long-lived nature and thus represent a unique cell type to understand the dynamics of proteostasis throughout development, maturation, and aging. Here, we u...

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Literature Corpus work
5fd6f84f-f880-54ad-87cd-4095054dc10d
DOI
10.1101/2025.08.11.669714
Open publication

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Proteostasis and Unfolded Protein Response Dynamics in Human Neuron and Mouse Glia Co-culture Reveal Cell-Specific Aging ResponsesDOI 10.1101/2025.08.11.669714
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