Article

DAF-16/Foxo suppresses the transgenerational sterility of <i>prg-1</i> piRNA mutants via a systemic small RNA pathway

2018-05-20

Abstract excerpt

Mutation of the daf-2 insulin/IGF-1 receptor activates the DAF-16/Foxo transcription factor to suppress the transgenerational sterility phenotype of prg-1 /piRNA mutants that are deficient for piRNA-mediated genome silencing. As with PRG-1/piRNAs, mutations in the nuclear RNA interference gene nrde-1 compromised germ cell immortality, but deficiency for daf-2 did not suppress the transgenerational sterility of...

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Literature Corpus work: 6e0066f8-91d1-5d47-8983-dabb69b6aa23
DOI: 10.1101/326751

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