Article
Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Cell reports - 25 Sept 2014
Barberán-Soler Sergio, Fontrodona Laura, Ribó Anna, Lamm Ayelet T, Iannone Camilla, Cerón Julián, Lehner Ben, Valcárcel Juan
Abstract excerpt
Many eukaryotic genes contain embedded antisense transcripts and repetitive sequences of unknown function. We report that male germline-specific expression of an antisense transcript contained in an intron of C. elegans Target of Rapamycin (TOR, let-363) is associated with (1) accumulation of endo-small interfering RNAs (siRNAs) against an embedded Helitron transposon and (2) activation of an alternative 3'...
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