Article

A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage

2022-03-04

Abstract excerpt

Germline integrity is critical for progeny fitness. Organisms deploy the DNA damage response (DDR) signalling to protect germline from genotoxic stress, facilitating cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous regulation of germline quality is well-studied; however, how quality is enforced cell non-autonomously on sensing somatic DNA damage is less known. Using Caenorhabditi...

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Literature Corpus work: 74292584-cd08-567e-9e0b-128cc9d1e349
DOI: 10.1101/2022.03.03.482777

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