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A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage

2022-01-21

Abstract excerpt

<title>Abstract</title> <p>Germline integrity is critical for progeny fitness. Organisms deploy the DNA damage response (DDR) signalling to protect germline from genotoxic stress, facilitating cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous regulation of germline quality is well-studied; however, how quality is enforced cell non-autonomously on sensing somatic DNA damage is less...

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Literature Corpus work
79fd3e2a-935f-59fc-805d-7f2e818a911e
DOI
10.21203/rs.3.rs-1119544/v1
Open publication

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A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damageDOI 10.21203/rs.3.rs-1119544/v1
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