Article

Clone decomposition based on mutation signatures provides novel insights into mutational processes

2021-05-10

Abstract excerpt

Intra-tumor heterogeneity is a phenomenon in which mutation profiles differ from cell to cell within the same tumor and is observed in almost all tumors. Understanding intra-tumor heterogeneity is essential from the clinical perspective. Numerous methods have been developed to predict this phenomenon based on variant allele frequency. Among the methods, CloneSig models the variant allele frequency and mutation sig...

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Literature Corpus work: 6ddbfdcd-d856-51a5-b34c-93914e9a7eab
DOI: 10.1101/2021.05.08.443215

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