CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data.

Abstract excerpt

Systematic DNA sequencing of cancer samples has highlighted the importance of two aspects of cancer genomics: intra-tumor heterogeneity (ITH) and mutational processes. These two aspects may not always be independent, as different mutational processes could be involved in different stages or regions of the tumor, but existing computational approaches to study them largely ignore this potential dependency. Here, we...

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