Article

Study of the RET receptor dysfunctions caused by mutations associated with human neoplastic disorders and developmental diseases

2004-01-01

Abstract excerpt

The ret proto-oncogene encodes a membrane spanning glycoprotein which is a member of the receptor tyrosine kinase family (Hanks et al. 1988). RET is the signaling component of multi-subunit receptor complexes for the GDNF of family ligands, including GDNF, neurturin, artemin and persephin. The binding components of these receptor complexes are glycosyl-phosphatidylinositol (GPI)-membrane anchored molecules, known...

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Literature Corpus work: 6dba8b42-0067-5892-b418-51b888914a5d
DOI: 10.21954/ou.ro.0000f9d0

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