Article

Structure-based mechanistic principles underlying the paradoxical effects of pathological RET mutations

2024-12-26

Abstract excerpt

<h4>ABSTRACT</h4> The RET receptor is a transmembrane protein that belongs to the receptor tyrosine kinase family. RET activates signaling pathways regulating cell growth, differentiation, and survival in diverse tissues that include the thyroid and enteric nervous system. Mutations that reduce RET levels or disrupt function can cause Hirschsprung’s disease (HSCR), characterized by abnormal distal colon innervati...

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Literature Corpus work: 4b72c816-bb9f-586c-a4b7-1616dbcf73a7
DOI: 10.1101/2024.12.26.630356

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