Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Current concepts in RET-related genetics, signaling and therapeutics.

Trends in genetics : TIG - 1 Nov 2006

Plaza-Menacho Ivan, Burzynski Grzegorz M, de Groot Jan Willem, Eggen Bart J L, Hofstra Robert M W

Abstract excerpt

The receptor tyrosine kinase RET is expressed in cell lineages derived from the neural crest and has a key role in regulating cell proliferation, migration, differentiation and survival during embryogenesis. Germline and somatic mutations in RET that produce constitutively activated receptors cause the cancer syndrome multiple endocrine neoplasia type 2 and several endocrine and neural-crest-derived tumors,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Haplotypes
Share to Hirschsprung Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiple Endocrine Neoplasia Type 2a

Share to NIH 3T3 Cells

Share to Polymorphism, Genetic

Share to Proto-Oncogene Proteins c-ret

Share to Signal Transduction

Source

Identifiers

PMID: 16979782
DOI: 10.1016/j.tig.2006.09.005

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Current concepts in RET-related genetics, signaling and therapeutics.PMID 16979782Read ↗

RET oncogene.Semantic proximity Read ↗

Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases.Semantic proximity Read ↗

RET in human development and oncogenesis.Semantic proximity Read ↗

RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.Semantic proximity Read ↗

The RET receptor: function in development and dysfunction in congenital malformation.Semantic proximity Read ↗

RET and neuroendocrine tumors.Semantic proximity Read ↗

RET tyrosine kinase signaling in development and cancer.Semantic proximity Read ↗

RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer.Semantic proximity Read ↗

RET mutations in multiple endocrine neoplasia type 2 and Hirschsprung disease.Semantic proximity Read ↗

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis.Semantic proximity Read ↗

RET and neuroendocrine tumors.Semantic proximity Read ↗

[From gene to disease; from the RET gene to multiple endocrine neoplasia types 2A and 2B, sporadic and familial medullary thyroid carcinoma, Hirschsprung disease and papillary thyroid carcinoma].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.