Mechanisms of development of multiple endocrine neoplasia type 2 and Hirschsprung's disease by ret mutations.

doi:10.1007/978-3-642-46870-4_14

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Article

Mechanisms of development of multiple endocrine neoplasia type 2 and Hirschsprung's disease by ret mutations.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 1998

Takahashi M, Asai N, Iwashita T, Murakami H, Ito S

Abstract excerpt

The ret proto-oncogene encodes a receptor tyrosine kinase whose ligands belong to the glial cell line-derived neurotrophic factor (GDNF) protein family. Its germline mutations are responsible for the development of multiple endocrine neoplasia (MEN) types 2A and 2B and Hirschsprung's disease (HSCR). MEN2A and MEN2B mutations result in the constitutive activation of Ret by different molecular mechanisms. MEN2A...

Topics

Drosophila Proteins
Glial Cell Line-Derived Neurotrophic Factor Receptors
Hirschsprung Disease
Humans
Multiple Endocrine Neoplasia Type 2a
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases

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Open in PubMed

Identifiers

PMID: 10027003
DOI: 10.1007/978-3-642-46870-4_14

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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