Article
RET oncogene.
Current opinion in genetics & development - 1 Feb 1996
Mak Y F, Ponder B A
Abstract excerpt
RET mutations have been identified as the underlying cause of two congenital diseases that predominately affect tissues of neural crest origin: the MEN 2 cancer syndromes and a proportion of cases of dominantly inherited Hirschsprung disease, a disorder of gut development. This review summarizes the disease-causing mutations and our present understanding of their possible effects on RET protein function.
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