Article
RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung's disease.
Pathology international - 1 Apr 2006
Asai Naoya, Jijiwa Mayumi, Enomoto Atsushi, Kawai Kumi, Maeda Kengo, Ichiahara Masatoshi, Murakumo Yoshiki, Takahashi Masahide
Abstract excerpt
Gain-of-function mutations within the receptor tyrosine kinase gene RET cause inherited and non-inherited thyroid cancer. Somatic gene rearrangements of RET have been found in papillary thyroid carcinoma and germline point mutations in multiple endocrine neoplasia (MEN) types 2A and 2B and familial medullary thyroid carcinoma (FMTC). Conversely, loss-of-function mutations are responsible for the development of...
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