Article
The RET proto-oncogene: a challenge to our understanding of disease pathogenesis.
Pediatric surgery international - 1 Jan 1997
Kusafuka T, Puri P
Abstract excerpt
RET gene alterations as disease-causative mutations have been demonstrated in five different disease entities: Hirschsprung's disease (HD); papillary thyroid carcinoma; and three types of inherited cancer syndromes: multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma. RET is expressed during embryogenesis in a temporally and spatially regulated manner, and plays an important...
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