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Article

Cellular mechanisms of RET receptor dysfunction in multiple endocrine neoplasia 2.

Endocrine-related cancer - 1 Jan 2025

Walker Timothy J, Mulligan Lois M

Abstract excerpt

Abstract: Rearranged during transfection (RET) is a developmentally important receptor tyrosine kinase that has been identified as an oncogenic driver in a number of cancers. Activating RET point mutations gives rise to the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN2), characterized by medullary thyroid carcinoma. There are two MEN2 subtypes, MEN2A and MEN2B, that differ in tumour...

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Identifiers

PMID: 39441865
DOI: 10.1530/ERC-24-0187

Genes

RET

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