Article

Genetic Variations In Human ATP2B4 Gene Alter Malaria Growth In Rbcs From Gambian Adults.

2022-02-15

Abstract excerpt

<h4>Background: </h4> Polymorphisms in ATP2B4 coding for PMCA4b, the primary regulator of erythrocyte calcium concentration, have been shown by GWAS and cross-sectional studies to protect against severe malaria but the mechanism remains unknown. <h4>Methods: </h4>: Using a recall-by-genotype design, we investigated the impact of a common haplotype variant in ATP2B4 using in vitro assays that model erythrocyte stag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6db30f2f-f989-5c65-87c0-76af920388d0
DOI: 10.21203/rs.3.rs-1347245/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Variations In Human ATP2B4 Gene Alter Malaria Growth In Rbcs From Gambian Adults.DOI 10.21203/rs.3.rs-1347245/v1Read

Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults.Semantic proximity Read

Decoding the multifaceted role of erythrocyte PMCA4b in oxidative stress-mediated malaria protection and artemisinin resistance.Semantic proximity Read

Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malariaSemantic proximity Read

Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria.Semantic proximity Read

Common host variation drives malaria parasite fitness in healthy human red cellsSemantic proximity Read

An ATP2B4 polymorphism protects against malaria in pregnancy.Semantic proximity Read

Genome-wide association study indicates two novel resistance loci for severe malaria.Semantic proximity Read

Decreased calcium pump expression in human erythrocytes is connected to a minor haplotype in the ATP2B4 gene.Semantic proximity Read

Common host variation drives malaria parasite fitness in healthy human red cells.Semantic proximity Read

Controlled Human Malaria Infection reveals that the Dantu blood group variant provides high level protection against uncomplicated malariaSemantic proximity Read

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Semantic proximity Read

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.Semantic proximity Read