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Article

Decoding the multifaceted role of erythrocyte PMCA4b in oxidative stress-mediated malaria protection and artemisinin resistance.

mBio - 14 Jan 2026

Agrohi Priya, Garg Swati, Biswas Shreeja, Maurya Preeti, Kumar Vijay, Sharma Jyoti, Goswami Bidhan, Sil Samir Kumar, Singh Mrigendra Pal, Chand Sunil Kumar, Shalini Sneh, Singh Om P, Dhangadamajhi Gunanidhi, Mishra Neelima, Ramalingam Sivaprakash, Mallick Prashant Kumar, Singh Shailja

Abstract excerpt

The ATP2B4 gene, encoding the PMCA4b Ca²+-ATPase in erythrocytes, has been linked to malaria protection via genome-wide association studies, though the proposed dehydration mechanism remains unclear. This study evaluates ATP2B4 genotypes and PMCA4b expression in malaria susceptibility and artemisinin sensitivity. ATP2B4 genotypes were compared across severe malaria, uncomplicated malaria, and healthy controls in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41400477
DOI: 10.1128/mbio.01738-25
PMCID: PMC12802218

Genes

ATP2B4
G6PD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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