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Article

Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults.

Malaria journal - 5 Jan 2023

Joof Fatou, Hartmann Elena, Jarvis Alison, Colley Alhassan, Cross James H, Avril Marion, Prentice Andrew M, Cerami Carla

Abstract excerpt

BACKGROUND: Polymorphisms in ATP2B4 coding for PMCA4b, the primary regulator of erythrocyte calcium concentration, have been shown by GWAS and cross-sectional studies to protect against severe malaria but the mechanism remains unknown. METHODS: Using a recall-by-genotype design, we investigated the impact of a common haplotype variant in ATP2B4 using in vitro assays that model erythrocyte stage malaria...

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Source

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Identifiers

PMID: 36604655
DOI: 10.1186/s12936-022-04359-4
PMCID: PMC9817369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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