Article

Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malaria

2024-12-18

Abstract excerpt

Artemisinin resistance in Plasmodium falciparum remains a major public health challenge for the ongoing malaria elimination programs. Till now, artemisinin resistance is linked with the variations in the genome of P. falciparum which are mainly clustered in the Pfkelch13 gene. Several studies reported artemisinin resistance in the malaria endemic areas without finding any evidence of genetic variation in parasit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61edd9f2-8065-5e4d-b22a-529714f33eb5
DOI: 10.1101/2024.12.17.628803

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malariaDOI 10.1101/2024.12.17.628803Read

Decoding the multifaceted role of erythrocyte PMCA4b in oxidative stress-mediated malaria protection and artemisinin resistance.Semantic proximity Read

Genetic Variations In Human ATP2B4 Gene Alter Malaria Growth In Rbcs From Gambian Adults.Semantic proximity Read

Genetic variations in human ATP2B4 gene alter Plasmodium falciparum in vitro growth in RBCs from Gambian adults.Semantic proximity Read

The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterationsSemantic proximity Read

Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria.Semantic proximity Read

Insights into the factors contributing to artemisinin resistance in Plasmodium falciparum.Semantic proximity Read

Peroxide antimalarial drugs target redox homeostasis in <i>Plasmodium falciparum</i> infected red blood cellsSemantic proximity Read

An evolutionary perspective of how infection drives human genome diversity: the case of malaria.Semantic proximity Read

Genetic polymorphisms linked to susceptibility to malaria.Semantic proximity Read

Human genetic variations conferring resistance to malaria.Semantic proximity Read

Human genetics and malaria resistanceSemantic proximity Read

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.Semantic proximity Read