Article
An ATP2B4 polymorphism protects against malaria in pregnancy.
The Journal of infectious diseases - 15 May 2013
Bedu-Addo George, Meese Stefanie, Mockenhaupt Frank P
Abstract excerpt
Polymorphisms of ATP2B4 encoding an ubiquitous Ca(2+) pump protect against severe childhood malaria. We assessed the influence of a main polymorphism (rs10900585) on malaria among 834 delivering Ghanaian women. In homozygous primiparae, the odds of placental Plasmodium falciparum infection were reduced by 64%. No influence of the polymorphism on parasite density, low birth weight, or preterm delivery was...
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