Article

Common host variation drives malaria parasite fitness in healthy human red cells

2020-10-09

Abstract excerpt

<h4>SUMMARY</h4> The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. The influence of host RBC variation on parasite replication is largely uncharted, aside from a handful of deleterious alleles like sickle cell. Here, we integrated analyses of exome sequencing, RBC phenotyping, and parasite fitness assays on blood from 122 indiv...

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Literature Corpus work: d44f6a94-14ad-5a57-8636-a9e277701ffe
DOI: 10.1101/2020.10.08.332494

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