Article

A Lymphotropic Biomimetic Nanoplatform Reverses Sleep Deprivation-Induced Cognitive Deficits by Reprogramming Microglial Phenotypes

2026-05-27

Abstract excerpt

<title>Abstract</title> <p> Sleep deprivation (SD) drives persistent neuroinflammation and cognitive impairment, yet the underlying cellular and molecular mechanisms remain incompletely understood. Using single-cell transcriptomics of SD mouse brains, we identify an irreversible microglial phenotype shift characterized by downregulation of the homeostatic marker Tmem119 and upregulation of the disease-associated...

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Literature Corpus work: 6db22031-8712-5b0f-9dc1-f95a062a9148
DOI: 10.21203/rs.3.rs-9719018/v1

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