Article

Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system

2025-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Improving siRNA delivery to the central nervous system (CNS) is a major focus for treating the numerous debilitating neurological conditions which have a genetic basis. Here, we present an albumin-binding siRNA based on an amphiphilic dendrimer conjugate (D-siRNA). We demonstrate that D-siRNA achieves effective and homogeneous delivery throughout the CNS following administration into the cerebro...

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Literature Corpus work: f4b7d383-2cd0-5b2b-a700-08e9ccaef7a3
DOI: 10.64898/2025.12.16.694641

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