Back to search

Article

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

2024-06-10

Abstract excerpt

Short-interfering RNA (siRNA) has gained significant interest for treatment of neurological diseases by providing the capacity to achieve sustained inhibition of nearly any gene target. Yet, efficacious drug delivery throughout deep brain structures of the CNS remains a considerable hurdle for intrathecally administered therapeutics. We herein describe an albumin-binding lipid-siRNA conjugate that transports along...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
98e6d2b3-57de-58fc-aecd-ac1d34cdbcaf
DOI
10.1101/2024.06.09.598079
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous systemDOI 10.1101/2024.06.09.598079
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrierSemantic proximity
Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous systemSemantic proximity
Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluidSemantic proximity
Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brainSemantic proximity
Quantitative Assessment of shRNA Loading and Delivery Efficiency of Engineered Extracellular VesiclesSemantic proximity
Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imagingSemantic proximity
Gene therapy and nanomedicine for meningioma treatmentSemantic proximity
Engineering mRNA-LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative diseasesSemantic proximity
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle DeliverySemantic proximity
A Lymphotropic Biomimetic Nanoplatform Reverses Sleep Deprivation-Induced Cognitive Deficits by Reprogramming Microglial PhenotypesSemantic proximity
A Rapidly Excretable, ROS-Scavenging Ionizable Lipid Decouples mRNA Delivery Potency from ToxicitySemantic proximity
Delivery of small-interfering RNA (siRNA) to the brainSemantic proximity
Select a neighboring publication to make it the new centre.