Article

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biology

2019-10-08

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are blood cancers characterized by excessive production of mature myeloid cells that result from the acquisition of somatic driver mutations in hematopoietic stem cells (HSCs) 1 . While substantial progress has been made to define the causal somatic mutation profile for MPNs 2 , epidemiologic studies indicate a significant heritable component for the disease that is among the...

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Literature Corpus work: 5f2cb692-5d3d-5e7f-854d-d0f557ff3902
DOI: 10.1101/790626

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