Article

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

2026-01-14

Abstract excerpt

Mutations in the epigenetic regulator ASXL1 are common in myeloid malignancies and portend a near-universally poor prognosis. While multiple mechanisms for mutant ASXL1-dependent oncogenesis have been proposed, none have been functionally validated in the context of the human hematopoietic stem cell, where these mutations almost certainly arise. Here, we extensively characterized a CRISPR-engineered human hematop...

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Literature Corpus work: 50aa2a43-9cbd-5ba4-b2ea-8b88e8db397c
DOI: 10.64898/2026.01.13.699315

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