Article

Minimal mechanistic component of proteasome activation and prevention of impairment by pathological oligomers

2021-09-23

Abstract excerpt

<title>Abstract</title> <p>Impairment of proteasomal function has been implicated in neurodegenerative diseases, justifying the need to understand how the proteasome is activated for protein degradation. Here, using biochemical and structural (cryo-EM) strategies in both archaeal and mammalian proteasomes, we further determine the HbYX(-motif)-dependent mechanism of proteasomal activation used by multiple proteas...

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Literature Corpus work: 6d910db5-cd0f-5506-9ac7-f1892e581124
DOI: 10.21203/rs.3.rs-900719/v1

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