Article

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

2024-01-28

Abstract excerpt

Dedicated assembly factors orchestrate stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here, we report cryo-EM reconstructions of seven recombinant human subcomplexes that visualize all five chaperones and the three active site propeptides across a wide swath of the assembly pathway. Comparison of these chaperone-bound interm...

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Literature Corpus work: d582d326-f218-5cbb-84a2-101537cb2b0f
DOI: 10.1101/2024.01.27.577538

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