Article

Allosteric regulation of the proteasome’s catalytic sites by the proteasome activator PA28γ /REGγ

2021-12-09

Abstract excerpt

Proteasome Activator 28γ (PA28γ) is a member of the 11S family of proteasomal regulators that is constitutively expressed in the nucleus and is implicated in certain cancers, lupus, rheumatoid arthritis, and Poly-glutamine neurodegenerative diseases. However, how PA28γ functions in protein degradation remains unclear. Though PA28γ’s mechanism has been investigated for some time, many alternative hypotheses have no...

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Literature Corpus work: 4e26bb10-d15b-5999-84c3-30ef1e7dd196
DOI: 10.1101/2021.12.09.471496

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