Article
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism.
The Journal of biological chemistry - 16 Dec 2011
Dange Thomas, Smith David, Noy Tahel, Rommel Philipp C, Jurzitza Lukas, Cordero Radames J B, Legendre Anne, Finley Daniel, Goldberg Alfred L, Schmidt Marion
Abstract excerpt
For optimal proteolytic function, the central core of the proteasome (core particle (CP) or 20S) has to associate with activators. We investigated the impact of the yeast activator Blm10 on proteasomal peptide and protein degradation. We found enhanced degradation of peptide substrates in the presence of Blm10 and demonstrated that Blm10 has the capacity to accelerate proteasomal turnover of the unstructured...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.