Article

Resolving the Activation Mechanism of the Human 20S Proteasome

2026-04-15

Abstract excerpt

Proteasome activators (PAs) bind the α-subunits of the human 20S proteasome (h20S), opening the “gates” and allowing entry of substrate proteins. Aging is associated with diminished proteasome activity, leading to interest in understanding this activation mechanism. Evolving models have been proposed regarding PAs C-terminal tails, yet the critical molecular contacts for gate-opening are unclear. Here, we show a c...

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Literature Corpus work: 51397ee7-5f96-5916-95e1-4c4f31bcd50f
DOI: 10.64898/2026.04.13.718244

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