Article

Minimal mechanistic component of HbYX-dependent proteasome activation

2023-03-20

Abstract excerpt

<title>Abstract</title> <p>The implication of reduced proteasomal function in neurodegenerative diseases combined with numerous studies showing the protective effects of increasing proteasome activity in animal models justify the need to understand how the proteasome is activated for protein degradation. The C-terminal HbYX motif is present on many proteasome binding proteins and functions to tether activators to...

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Literature Corpus work: 5fde0e2d-ca5a-5e9a-9cbf-4ef66247a3a9
DOI: 10.21203/rs.3.rs-2496767/v1

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