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Article

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.

Molecular cell - 9 May 2008

Rabl Julius, Smith David M, Yu Yadong, Chang Shih-Chung, Goldberg Alfred L, Cheng Yifan

Abstract excerpt

Substrates enter the cylindrical 20S proteasome through a gated channel that is regulated by the ATPases in the 19S regulatory particle in eukaryotes or the homologous PAN ATPase complex in archaea. These ATPases contain a conserved C-terminal hydrophobic-tyrosine-X (HbYX) motif that triggers gat...

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Identifiers

PMID: 18471981
DOI: 10.1016/j.molcel.2008.03.004
PMCID: PMC4141531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18471981-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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