Article

Structural basis of human 20S proteasome biogenesis

2024-08-08

Abstract excerpt

<h4>ABSTRACT</h4> New proteasomes are produced to accommodate increases in cellular catabolic demand and prevent the accumulation of cytotoxic proteins. Formation of the proteasomal 20S core complex relies on the function of the five chaperones PAC1-4 and POMP. To understand how these chaperones facilitate proteasome assembly, we tagged the endogenous chaperones using CRISPR/Cas gene editing and examined the chap...

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Literature Corpus work: e2a87103-04c2-544b-a79a-c4cedca1eea2
DOI: 10.1101/2024.08.08.607236

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