Article

The amyloid precursor protein modulates the position and length of the axon initial segment offering a new perspective on Alzheimer’s disease genetics

2022-01-24

Abstract excerpt

The small Aβ peptide has been hypothesized to be the main driver of Alzheimer’s disease (AD). Aβ is a proteolytic cleavage product of a larger protein, the amyloid precursor protein (APP), whose normal functions remain largely unexplored. We report here activities of the full-length APP protein that relate directly to the etiology of AD. Increasing neuronal activity leads to a rapid increase in App gene expressio...

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Identifiers and source

Literature Corpus work: a95c645a-94ef-592d-8857-8be195f0d7c4
DOI: 10.1101/2022.01.23.477413

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