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Function and Dysfunction of Presenilin

2 Oct 2013

Abstract excerpt

The presenilin(PS) genes harbor approximately 90% of the identified mutations linked to familial forms of Alzheimer's disease, and the presenilin (PS) proteins are essential components of the γ-secretase complex involved in the proteolytic cleavage of type I receptors, such as Notch and the amyloid precursor protein. Genetic analysis employing cell type-specific conditional knockout technology highlighted the...

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PMID: 24107444
DOI: 10.1159/000354971

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