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Article

Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.

Science signaling - 6 Sept 2016

Tong Benjamin Chun-Kit, Lee Claire Shuk-Kwan, Cheng Wing-Hei, Lai Kwok-On, Foskett J Kevin, Cheung King-Ho

Abstract excerpt

Some forms of familial Alzheimer's disease (FAD) are caused by mutations in presenilins (PSs), catalytic components of a γ-secretase complex that cleaves target proteins, including amyloid precursor protein (APP). Calcium (Ca(2+)) dysregulation in cells with these FAD-causing PS mutants has been attributed to attenuated store-operated Ca(2+) entry [SOCE; also called capacitative Ca(2+) entry (CCE)]. CCE occurs...

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Source

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Identifiers

PMID: 27601731
DOI: 10.1126/scisignal.aaf1371
PMCID: PMC5384262

Genes

STIM1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.PMID 27601731Read ↗

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