Article
Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease.
Neuromolecular medicine - 1 Jan 2002
Chan Sic L, Furukawa Katsutoshi, Mattson Mark P
Abstract excerpt
A key neuropathological hallmark of Alzheimer's disease (AD) is the loss of neocortical and hippocampal synapses, which is closely correlated with the degree of memory impairment. Mutations in the genes encoding the amyloid precursorprotein (APP) and presenilins are responsible from some cases of early-onset autosomal-dominant AD. This article reviews the current understanding of how alterations in the cellular...
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