Article

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathway

2026-07-30

Abstract excerpt

<title>Abstract</title> <p> FLT3-ITD mutations in acute myeloid leukemias (AMLs) cause ligand-independent signaling. One way signaling pathways potently and immediately influence cell fates is by phosphorylating key fate-determining proteins to trigger their proteolysis. We investigated the master transcription factor (MTF) driver of granulo-monocytic lineage-fates, CEBPA, for regulation by this mechanism becaus...

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Literature Corpus work: 6d7650fb-f8a6-5e36-865a-d98dd509e9ef
DOI: 10.21203/rs.3.rs-10436387/v1

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