Article

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes inhibitor resistance mechanisms of acute myeloid leukemia cells

2025-07-25

Abstract excerpt

<title>Abstract</title> <p>Background The hyperactive kinase FLT3-ITD drives acute myeloid leukemia (AML) and is a diagnostic, prognostic, and predictive biomarker. We aimed to identify targeted protein degraders for FLT3-ITD that disengage drug resistance mechanisms of AML cells. Methods We synthesized and characterized MA191 as novel von Hippel-Lindau (VHL)-based proteolysis targeting chimera (PROTAC) for FLT3....

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Literature Corpus work: 38734c2a-2e09-5d01-9b82-afa8abb24ad3
DOI: 10.21203/rs.3.rs-7166736/v1

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