Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination

5 Jul 2025

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy with a poor prognosis, despite advancements in treatment. Many patients struggle with relapse or refractory disease. Investigating the role of the super-enhancer (SE) regulated gene ubiquitin-specific protease 20 ( USP20 ) in T-ALL could enhance targeted therapies and improve clinical outcomes. Analysis of histone H3 lysine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Genetics and Neurodevelopmental Disorders
Share to T-cell and Retrovirus Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41049757
DOI: 10.1016/j.apsb.2025.07.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitinationPMID 41049757Read ↗

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell LeukemiaSemantic proximity Read ↗

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemiaSemantic proximity Read ↗

The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeuticsSemantic proximity Read ↗

A pan-cancer analysis of USP5: its diagnostic, prognostic and immunological roles in human cancersSemantic proximity Read ↗

Ubiquitin-specific peptidase 10, a deubiquitinating enzyme: Assessing its role in tumor prognosis and immune responseSemantic proximity Read ↗

A pan-cancer analysis of the role of USP5 in human cancersSemantic proximity Read ↗

Integrative and Comprehensive Pan-cancer Analysis of Ubiquitin Specific Peptidase 11 (USP11) As a Prognostic and Immunological BiomarkerSemantic proximity Read ↗

USP18 regulates the malignant phenotypes of glioblastoma stem cells.Semantic proximity Read ↗

Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children.Semantic proximity Read ↗

DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of DeubiquitinasesSemantic proximity Read ↗

Emerging Role of Ubiquitin-Specific Protease 19 in Oncogenesis and Cancer DevelopmentSemantic proximity Read ↗

Targeting deubiquitinase USP28 for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.