Article
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia.
Science advances - 21 Jan 2022
Han Cuijuan, Khodadadi-Jamayran Alireza, Lorch Adam H, Jin Qi, Serafin Valentina, Zhu Ping, Politanska Yuliya, Sun Limin, Gutierrez-Diaz Blanca T, Pryzhkova Marina V, Abdala-Valencia Hiam, Bartom Elizabeth Thomas, Buldini Barbara, Basso Giuseppe, Velu Sadanandan E, Sarma Kavitha, Mattamana Basil B, Cho Byoung-Kyu, Obeng Rebecca C, Goo Young Ah, Jordan Philip W, Tsirigos Aristotelis, Zhou Yalu, Ntziachristos Panagiotis
Abstract excerpt
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition blocks T-ALL growth in vivo with no notable associated toxicity. We also revealed protein stabilization of the U2 complex component SF3B1 via deubiquitination. Our...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.