Article

FLT3-ITD signals for CEBPA and p53 proteolysis by the ubiquitin-proteosome pathway

2026-07-15

Abstract excerpt

<h4>ABSTRACT</h4> Internal-tandem-duplication of the receptor tyrosine kinase FLT3 ( FLT3-ITD ) generates ligand-independent signaling and is highly recurrent in acute myeloid leukemias (AMLs). One way signaling pathways can quickly influence cell fates is by phosphorylating key fate-determining proteins to trigger their proteolysis. We investigated the master transcription factor (MTF) driver of granulo-monocy...

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Literature Corpus work: 70590cbb-4a87-57ea-90f4-2a28a2bac1b6
DOI: 10.64898/2026.07.14.738455

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