Article

Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic function

2023-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Precise temporal regulation of Type I interferon signaling is imperative to effectively fight infections and cancerous cells without triggering autoimmunity. The key negative regulator of Type I interferon signaling is ubiquitin-specific protease 18 (USP18). USP18 cleaves interferon-inducible ubiquitin-like modifications through its canonical catalytic function and directly inhibits interferon r...

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Literature Corpus work: 7bbf4770-6ed4-5f2a-be6a-d057a9ee6b48
DOI: 10.1101/2023.03.23.533924

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