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Article

Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML.

International journal of molecular sciences - 26 Sept 2024

Nogami Ayako, Amemiya Hideki Jose, Fujiwara Hiroki, Umezawa Yoshihiro, Tohda Shuji, Nagao Toshikage

Abstract excerpt

FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations in acute myeloid leukemia (AML) are associated with poor prognosis and therapy resistance. This study aimed to demonstrate that inhibiting the deubiquitinating enzymes ubiquitin-specific peptidase 14 (USP14) and ubiquitin C-terminal hydrolase L5 (UCHL5) (USP14/UCHL5) with b-AP15 or the organogold compound auranofin (AUR) induces...

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Identifiers

PMID: 39408703
DOI: 10.3390/ijms251910372
PMCID: PMC11476563

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