Article

USP7 as part of non-canonical PRC1.1 is a druggable target in leukemia

2017-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Acute myeloid leukemia (AML) is a highly heterogeneous disease in which genetic and epigenetic changes disturb regulatory mechanisms controlling stem cell fate and maintenance. AML still remains difficult to treat, in particular in poor risk AML patients carrying TP53 mutations. Here, we identify the deubiquitinase USP7 as an integral member of non-canonical PRC1.1 and show that targeting of USP...

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Literature Corpus work: 44b8736a-d8ee-53e6-a43c-d9b07c3a6b51
DOI: 10.1101/221093

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