Article

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes tyrosine kinase inhibitor resistance of acute myeloid leukemia cells

2025-06-26

Abstract excerpt

<h4>Background</h4> Feline McDonough sarcoma (FMS)-related receptor tyrosine kinase 3 with activating internal tandem duplications (FLT3-ITD) causes acute myeloid leukemia (AML). Targeted protein degraders for FLT3 have evolved as drugs against leukemia. <h4>Methods</h4> We synthesized and characterized MA191 as novel von Hippel-Lindau (VHL)-based proteolysis targeting chimera (PROTAC) for FLT3. We analyzed prot...

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Literature Corpus work: 6c5164b6-9054-53df-a32c-9360b1b64492
DOI: 10.1101/2025.06.20.660791

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