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TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

1 Feb 2020

Abstract excerpt

TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q. Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity. Expression of TIFAB in hematopoietic stem/progenitor cells (HSPCs) permits USP15 signaling to substrates, including...

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PMID: 32101751
DOI: 10.1016/j.celrep.2020.01.093

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