Article

The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation

2017-09-11

Abstract excerpt

UHMK1 (KIS) is a nuclear serine/threonine kinase that possesses a U2AF homology motif and phosphorylates and regulates the activity of the splicing factors SF1 and SF3b155. Mutations in these components of the spliceosome machinery have been recently implicated in leukemogenesis. The fact that UHMK1 regulates these factors suggests that UHMK1 might be involved in RNA processing and perhaps leukemogenesis. Here we...

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Literature Corpus work: ebc4f193-61c2-5192-8d0b-10698716c027
DOI: 10.1101/187385

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